Clinical Psychiatry News - Nortriptyline and smoking
Smokers who try to quit smoking with nortriptyline have a higher success rate than those who use placebo, especially if they are highly dependent on nicotine, reported Dr. Celia Lidia da Costa and her colleagues at the A.C. Camargo Cancer Hospital, Sao Paulo, Brazil.
Overall, 38 of the 68 patients in the nortriptyline group were able to stop smoking for at least 1 week by the end of 6 weeks of treatment, a significantly greater success rate than what was achieved by 18 of 76 patients in the placebo group in the prospective, randomized, double-blind trial (Chest 122[2]:403-08, 2002).
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However, 29 (60%) of the 48 smokers in the nortriptyline group with a high level of nicotine addiction quit smoking, which was significantly higher than 4 (7%) of 57 similar smokers in the placebo group.
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